MassWorks----質譜軟件革命 |
廣大的質譜用戶可以在常規的、單位質量分辨率的質譜儀上,對化合物進行高準確度的質量測定......[全文] |
快來聽!MassWorks發明人講座 | 質譜+MassWorks給您更好的有機物定性結果 |
高/低分辨質譜上的解決方案 | 未知物鑒定:1ppm夠么? |
中國CIQ用戶國外論文 | 和Agilent共同開發GC/MS上應用 |
MassWorks部分國內外用戶名單 更多用戶>>
|
非法添加物的篩查 |
天然產物中未知物的識別 |
藥物/原料藥中雜質的鑒定 |
復雜生物基質中代謝物的鑒定和識別 |
儀器安全分析中陽性結果的確證 |
目標物精確質量數的測定 |
突發、應急目標物的識別 |
環境污染分析 |
有機合成化合物的鑒定 |
組織切片的質譜成像分析 |
手性藥物的定量分析 |
評價質譜儀器狀態 |
MassWorks是一個非常有效的分子式識別工具,對我們從事的天然產物未知物鑒別工作很有幫助,尤其對共流出物的化合物識別,起到關鍵的作用,彌補了NIST譜庫的不足。對低分辨的氣質以及高分辨的液質,可以大大提高化合物分子式的確認準確度。
甘肅省出入境檢驗檢疫局檢驗檢疫技術中心----周圍主任
"The ability to provide the elemental identification of unknown compounds on a routine basis by any scientist is now within one"s reach."
Eli Lilly Poster from ASMS 2007
由于MassWorks的超越性能,對任何從事質譜分析的人確定分子式已成為舉手之勞。
"Congratulations!! Once more I are am deeply impressed by sClips. In both cases you are right with the top no. 1 [formula]!! Additionally, I find it fantastic that you do not need a calibration standard for higher resolving mass specs, by “just” looking at the isotope signals."
Communication from blind sample evaluation on a Leco LC-TOF Prof. Dr. Wolfgang Schwack Universit?t Hohenheim, Germany
“祝賀你們, sCLIPS再一次給我留下深深的印象。 兩次的盲樣測試,你們鑒定的分子式的第一選擇都是正確的結果。此外,我發現對高分辨質譜數據,你們竟然不需要利用標準化合物進行標定,僅僅利用同位素的信號就可以做分子式的鑒定。 這簡直是太神奇了。”
這是西瓦克教授在兩次盲樣測試(Leco LC-TOF)得到正確結果后的感受。
"With PFTBA calibration performed to each GC/MS run, mass accuracy better than 10mDa can be achieved and Spectral Accuracy of better than 99% can be achieved to help attain reliable formula determination. The mass calibration is stable after 11 days without significantly compromising formula determination. While mass calibration is more susceptible to time related variations, the Spectral Accuracy has been shown to be robust enough for formula determination after 19 days."
Boehringer Ingelheim Pharmacueuticals Poster from ASMS 2008
MassWorks 利用PFTBA標定氣質數據,質量準確度與譜圖準確度能分別達到小于10 毫道爾頓和99%., 從而可以進行可靠的分子式鑒定。PFTBA標定相當穩定。同樣的標定在11天內產生幾乎相似的鑒定結果。質量準確度易于隨時間漂移,但譜圖準確度可保持長達19天幾乎不變,從而更適用于分子式鑒定。
"The program is very easy to learn, it literally took minutes to get the first exciting results. On our 10 year-old triple quad, we manage to achieve mass accuracies of 10ppm or better routinely. It has become an integral part of our characterization pipeline for newly synthesized compounds."
Dr. Alexander Leitner University of Vienna
“使用MassWorks非常簡單,一學就會。我僅僅花了幾分鐘的時間就得到了第一次振奮人心的結果。我們在使用了十年有余的三重四極桿上,通常可以達到10 ppm 或者更好的質量準確度。這個軟件已成為我們鑒定合成化合物的重要組成部分。”
"Determining the elemental composition of pure materials at modest resolution typical of quads has never been routinely practiced – CLIPS brings that task very close to practice for the general user. It is not too much of a stretch to suggest CLIPS will enhance the confidence of TOF-based assignments as well, which may even challenge slower FTMS-based determinations."
User at a large midwest consumer products company
用低分辨率四極桿質譜儀可靠地確定純化合物是史無前例的–CLIPS給眾多的四極桿質譜儀操作人員。可以并不夸張地說sCLIPS會幫助由時間飛行質譜儀或傅里葉變換質譜儀進一步準確地鑒定未知化合物。
"The accurate mass profile extract ion chromatogram (AMPXIC) obtained through accurate mass measurement and isotope profile-mode filtering [performed with MassWorks] eliminated the false positive peaks observed using conventional XIC in the metabolite profile."
Wyeth Research Poster from ASMS 2008
比起通常離子提取圖,準確質量輪廓離子提取圖去除了許多在代謝產物分析中的假陽性峰
恵氏公司研究人員 (ASMS2008)
"I have tested and used the MassWorks software since the summer of 2007. The main purpose for me is using its formula ID feature to confirm the GC/MS NIST library search results for unknown chemical substance identification especially when the [NIST] search match values are similar for more than one compounds. The software is relatively simple to use and most times provides the #1 match for our testing chemicals with more than 200 compounds in a variety of chemical groups."
User from a United States Government Environmental Lab
自從2007年夏季我就測試和使用MassWorks這個軟件。我的主要目的是應用這個軟件鑒定分子式的性能去進一步核實氣質未知化合物NIST譜庫檢索的結果。尤其是當檢索結果顯示多種化合物具有相似匹配值時,MassWorks會提供另一個獨立的分子式幫助確定未知化合物。相對來說,這個軟件簡單易用。在我所測試的各種類型多于二百的化合物中,大部分由MassWorks分析結果都將正確的分子式排在第一位。
美國一州政府環保實驗室用戶
"Starting a little bit "speechless" from our side your Presentation helped really changing our mindset, from "unbelieving into "believer". After this Test with a sample taken from real life with real interferences my colleagues and I fully agree that MassWorks is indeed a powerful tool for advanced GC/MS analysis. We found that MassWorks is really a "must have" product for us..."
Researcher from a large German chemical company
一開始,我們被你們的結果驚訝得啞口無言。你們的講座和演示真正地改變了我們的觀念。真是千聞不如一見。在經過具有干擾的實際樣品的盲樣測試后, 我和我的同事都一致認為MassWorks確實是用于氣質分析十分有效的工具。我發現MassWorks是我們是必不可少軟件。
德國一家大型化工廠的研究人員