2008年ASMS的綜述：解析液質市場

ASMS 2008: new products and previews.

http://www.allbusiness.com/trends-events/conferences-conventions/11432335-1.html

Publication: Instrument Business Outlook
Date: Sunday, June 15 2008

這是看到網上的一篇報道，挺有意思。

The 56th American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics (ASMS) was held at the Denver, Colorado, convention center from June 1 to June 5. The ASMS meeting continued its trend of increasing attendance, which was up close to 2% to 6,569. The number of exhibitors dropped by 12 to 171 this year after increasing nearly 30% in 2007 (see IBO 6/15/07). Many of the exhibitors that were in attendance were more active than in previous years, with more end-users' meetings on the preceding weekend and five press conferences, in contrast to the three press conferences held at 2007's meeting.

講的是2008年在美國丹佛召開的第56屆ASMS會議。參加者為6569人，展商為171個。

This year's ASMS meeting featured more than 2,500 presentations, in addition to the many oral presentations, lunch meetings and working group meetings. The number of abstracts in nearly all major product categories was up from 2007 (see graph, page 8). The most dramatic increase was for Q-Trap, for which the number of abstracts mentioning the technique nearly doubled. However, this number was only slightly higher than In 2006. This year, there were more abstracts on GC/MS, triple quadrupole and FT-ICR than in the last five years, which is likely related to the increasing activities In the environmental and food industries.

有2500個演講，QTrap發表的數量翻了近一倍，還有很多氣質聯用，三重四極桿和FT-IR的摘要。

Several of the major MS vendors introduced new instruments at the show this year, with an obvious focus on triple quadrupole and Q-TOF LC/MS systems. Some ASMS continued from page 1 of the new introductions, however, will not be ready to ship until 2009, demonstrating an eagerness on the part of some vendors to begin wooing potential customers quite early.

幾個主要的質譜廠商發布了新儀器，大多數聚焦在三重四極桿和Q-TOF領域。

Thermo Fisher Scientific introduced two new systems at this year's ASMS, including an addition to its TSQ triple quadrupole LC/MS line, and an all-new LC/MS instrument based on the company's hugely successful Orbitrap mass analyzer. Thermo's new TSQ Vantage is positioned above the current Ultra and Access models of the TSQ product line, and has 10 times the sensitivity of the Ultra, according to the company, which is primarily due to its next-generation optics. The TSQ Vantage is priced to compete with upper-tier tandem LC/MS systems in the $400,000-$450,000 range, and is now shipping.

Thermo推出了兩個新系統。TSQ Vantage三重四極桿液質，和使用了Orbrap技術的Exactive。TSQ Vantage定位在超高端的領域，比TSQ Ultra提高了10倍靈敏度，主要的貢獻來源于離子傳輸光學部分的改進。TSQ Vantage的售價大致在40~50萬美元。

Also introduced by Thermo at ASMS was the Exactive benchtop LC/ MS system, which is based around the Orbitrap mass analyzer, in contrast to Thermo's LTQ-Orbitrap and LTQ-FT, the Exactive is not a tandem system, which greatly lowers its price, but it can still provide MS/MS. In addition, the Exactive has the same HCD (higher collision decomposition) scanning capability of the LTQ-Orbitrap, but is a faster system, providing 10,000 resolution at 10 scans per second, or 100,000 resolution at 1 scan per second. Despite the fact that the Exactive is categorized as an FT/MS, it is priced and positioned to compete against LC-TOF and LC-Q-TOF instrumentation. The Exactive will be priced in the $250,000-$350,000 range and the first shipments are expected by October.

Thermo還推出了臺式的包含Orbitrap分析器的Exactive儀器，因為它不是串聯的儀器，所以大幅降低了價格，但其實，Exactive仍可以提供串聯質譜MS/MS功能。除此之外，Exactive有和Orbi同樣的HCD（高能碰撞解離）能力，但采集速度更快，可每秒獲得10張10,000分辨率的譜圖，或者每秒獲得1張高達100,000分辨率的譜圖。Exactive是同LC-TOF和LC-Q-TOF競爭的產品，價位大致在25~35萬美元。

Thermo also introduced new software and consumables products. The Proteome Discoverer proteomics analysis software, which will replace the company's Bioworks software, enables the comparison of MS data from a multitude of sources and comes with a SEQUEST license. Introducing a new labeling technology for protein quantitation, Thermo Scientific released the TMT Isobaric Mass Tagging Kits, based on technology exclusively licensed from Proteome Sciences.

Thermo還推出了新軟件和耗材產品。Proteome Discoverer蛋白質組學分析軟件，將取代公司的Bioworks軟件，可對來自不同來源處的質譜數據進行比對。Thermo還推出了用于蛋白質定量的新的標記技術，TMT同位素質量標簽解決方案包。

Bruker introduced an all-new high-end LC/MS Q-TOF system that is built to achieve high-resolution along with high-speed. The new maXis system has a resolution of 40,000-60,000 when scanning at 20 spectra per second, and a 1 ppm mass accuracy for both MS and MS/MS, according to Bruker. Despite being a very tall floor-standing system, the maXis is designed to take up a very small footprint, and operates on standard single-phase power. Bruker's primary competitive target for the maXis is Thermo's LTQ-Orbitrap product line. The starting US list price for the maXis is $575,000 and it is expected to begin shipping in September. One other item of note from Bruker at ASMS was its announcement of a GC-APCI interface for its micrOTOF II LC/MS TOF instrument, which was introduced at Pittcon (see IBO 3/15/08). This is a new direction for Bruker, as the company has not actively developed or marketed products for the GC/MS market before.

Bruker公司推出了新的高端Q-TOF，可獲得高分辨和高速度。新的maXis系統具有40,000 ~ 60,000的分辨率，同時可每秒采集20張譜圖，不管對MS還是MS/MS，都可獲得1 ppm的質量精度。maXis是立式的，雖然很高，但是占地很小，也僅需要標準的單相供電。maXis是專門針對Orbitrap的競爭產品，起價定在57.5萬美元。Bruker還推出了GC-APCI接口，用于其micrOTOF II LC/MS 飛行時間質譜。這是Bruker公司的一個新方向，即也開始挺進GC/MS市場。

Agilent introduced a trio of new instruments at ASMS, including a triple quadrupole LC/MS, an LC/MS QTOF and a triple quadrupole GC/MS. Agilent's 6460 is a new addition to its 6400 Series triple quadrupole LC/MS product line, which has been wildly successful since Agilent's recent entrance into this market segment. The 6460 features subfemtogram sensitivity, thanks largely to Agilent's new Jet Stream technology for enhancing the ionization and nebulization processes, which is an integrated part of the system. The Jet Stream technology also features prominently on Agilent's new 6530 LC/MS Q-TOF system, which is the third model in the 6500 product line. Agilent claims the 6530 has better than 50,000 resolution when run at 20 scans per second. US pricing for the 6460 starts at $350,000, and pricing for the 6530 starts at $505,000. Both models are set to begin shipping this September.

Agilent推出了三重四極桿液質、Q-TOF液質，和三重四極桿氣質。6460是加入6400系列的一款新型三重四極桿液質，特點是：由Jet Stream噴射粒子流技術產生的fg級靈敏度，該技術提高了離子化和霧化效率。Jet Stream技術同時也用于Agilent的6530 Q-TOF液質系統，該系統具有超過50,000的分辨率，同時可每秒采集20張譜圖。6460在美國起價為35萬美元，6530起價為50.5萬美元。

Also new from Agilent at the show was its 7000A triple quadrupole GC/MS. The system marks Agilent's entry into the triple quadrupole GC/ MS market, and makes it the fourth major competitor in the segment (see IBO 2/29/08). The 7000A is heavily based on Agilent's 5975C GC/MSD in terms of both external feel, the interface for the user, the quartz quadrupole mass analyzer and other internal components of the system. This was a very early preview of the system, as Agilent does not expect to begin shipping the 7000A until January 2009. Pricing has yet to be determined, but is expected to be between $200,000 and $250,000. Agilent also announced its new Triple Axis detector for the 5973 GC/MSD, which is also available as an upgrade to existing systems at a price between $3,000 and $4,000.

Agilent還推出了7000A三重四極桿的氣質聯用，意味著Agilent成為該類型儀器的第4家供應商（其余包括：Waters、Varian和Thermo）。7000A基于Agilent的5975C 氣質聯用技術，石英四極桿質量分析器、外部、內部組件和用戶界面都類似，雖然價格還未公布，但預期其價格將在20~25萬美元。Agilent也發布了用于5973 GC/MSD的三軸檢測器，價格大概為3000~4000美元。

Waters introduced a new high-end triple quadrupole LC/MS, as well as its own version of an external column nanoLC system. Waters' new Xevo, its next-generation triple quadrupole LC/MS, has selected by IBO as this year's best new product at ASMS (see page 6). The Xevo makes use of a novel CID (collision-induced dissociation) technology that incorporates Waters' Scanwave technology, which provides additional selectivity. Waters intends for the Xevo to eventually replace its successful Quattro Premier XE. The Xevo is priced starting near $450,000 and is expected to begin shipping in the third quarter. Also new from Waters at the show was the Trizaic UPLC, which is a tile-based nanoscale HPLC system. The Trizaic combines Waters' UPLC technology with individual tiles that act as cartridges or chips that include a nanoscale column. ASMS was a preview of the Trizaic, which is not expected to ship until early 2009.

Waters發布了新型高端三重四極桿液質，和它自己的連接外部色譜柱的納升級液相系統。推出的Xevo是一代新型三重四極桿液質，被IBO評選為年度最佳產品。Xevo使用新型CID技術，并結合了Waters的Scanwave技術，提供了更多的選擇性。Waters希望最終Xevo取代它成功的Quattro Premier XE產品。Xevo的起價為45萬美元。Waters還推出了Trizaic UPLC，是一臺納升級的液相，并采用了Waters UPLC的技術，包括管朱、芯片、納升級流速的柱子。

Among other major MS vendors, Shimadzu had rolled out a revamped line of MALDI-TOF instruments earlier this year at Pittcon, but did not promote them heavily at ASMS. The line consists of the AXIMA Performance reflectron MALDI TOF/TOF MS for C1D MS/MS, the AXIMA Confidence reflectron MALDI-TOF MS and the AXIMA Assurance linear MALDI-TOF MS. Applied Biosystems introduced a host of new software products that are generally targeted at nonexperts and designed for ease of use.

在其它的主要質譜供應商中，島津公司展示了其在當年Pittcon上發布的MALDI-TOF，但沒有在ASMS上重點推廣。這條MALDI-TOF線包括其AXIMA MALDI TOF/TOF質譜儀，AXIMA MALDI TOF反射型質譜儀，和AXIMA MALDI TOF線型質譜儀。AB公司介紹了其一系列新軟件，這些軟件主要為非專家級的用戶設計，使其易于使用。

There were very few other introductions of systems or major related equipment. The recently created 1st Detect division of Spacehab showed its new Miniature Mass Spectrometer, which is based on the same ion trap technology that Spacehab developed for NASA. The new system weighs less than 15 lbs, has a mass range of 1-300 amu and MS" capability. 1st Detect plans to market the system to the military and first responders. The system will be available in the third quarter with a price point of well under $50,000.

Spacehab展示了其小型質譜，它和Spacehab為NASA（美國宇航局）設計的離子阱質譜是類似的。新的系統不到15磅重，質量范圍1~300 amu。Spacehab公司希望該儀器售給軍方和快速反應部門。這臺小型質譜的售價將低于5萬美元。

ASMS 2008 Product of the Show

IBO has selected Waters' new Xevo triple quadrupole LC/MS as the best new product from this year's ASMS meeting. While this new benchtop system certainly has a modern look, consistent with its name, it is the collision cell technology on the inside that made IBO take notice.

Waters公司的Xevo三重四極桿液質被IBO評為2008年度ASMS最佳新產品。這套臺式的系統外觀時尚，其內部獨有的碰撞池技術使IBO選擇了它。

The Xevo's novel collision cell design enables it to operate in T-Wave mode or in Waters' more recently developed ScanWave mode. T-Wave mode utilizes a stacked-ring ion guide design that allows it to produce a traveling wave that accelerates ions into the second quadrupole mass analyzer. This has the effect of significantly improving the fast scanning abilities of a tandem MS.

Xevo的新型碰撞池設計使它可操作在T-Wave模式或新的ScanWave模式下，T-Wave模式使用了堆疊的環形離子透鏡技術，可以產生一種Traveling的行波來加速離子進入第二個四極桿分析器。該技術可顯著提高串聯質譜的掃描速度。

Perhaps the more interesting capability is the ScanWave mode of the collision cell, which functions as a sort of ion trap. In ScanWave mode, ions are accumulated and then selectively gated into the second quadrupole. This helps the Xevo to significantly increase the signal intensity of both parent and product ion spectra. In comparison to Waters' current state-of-the-art triple quadrupole LC/MS, the Quattro Premier XE, Waters claims that the Xevo attains as much as eight times the response as a result of the new collision cell design.

更有趣的是碰撞池的ScanWave模式，很像一個離子阱。在ScanWave模式下，離子被累積并選擇性地進入第二個四極桿。這使Xevo顯著提高了母離子和子離子的響應信號。而比較Waters自己成功的三重四極桿液質Quattro Premier XE，Waters說它的Xevo由于新的碰撞池設計，其信號響應是Quattro Premier XE的8倍。

While the collision cell is the centerpiece of the new Xevo, other improvements have been included as well. The system features Waters' IntelliStart technology, which was first introduced on the lower-end SQD and TQD LC/MS systems. It is intended to automate much of the instrument checks and calibration needed for operation. Waters clearly hopes to put a much more powerful LC/MS system in the hands of non-mass spectroscopists. The Xevo also features the latest generation of Waters' ZSpray ionization source, which is an integrated design that allows users to switch between various sources without any tools.

碰撞池技術的改變是核心，Waters還有其它的一些技術提高。比如智能開啟（IntelliStart ）技術，第一次引入到其較低端的SQD和TQD液質中。這項功能可以自動完成大部分的儀器操作前的自檢和校正功能。Waters顯然希望將其LC/MS技術推給更多的非質譜專家。Xevo也具有最新一代的ZSpary離子化技術，這是一套集成的設計，使用戶可以無需工具地在各種不同的離子源間切換。

The new Xevo appears to be a significant improvement in the triple quadrupole LC/MS market and should help position Waters regain some of the ground it lost in the segment several years ago. Waters intends to price the Xevo at or slightly above current top-end triple quadrupole LC/MS systems that are currently on the market.

新的Xevo是三重四極桿液質市場上的一個顯著提高，幫助Waters收復幾年前丟掉的部分市場，Waters想把Xevo定位在比最高端三重四極桿液質還高一點的價位。