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Less?common?disorders:C

關鍵詞： less common disorders c來源：互聯網

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DISEASE AND CAUSES	PATHOPHYSIOLOGY	SIGNS AND SYMPTOMS
*Cancer of the vulva*	?
Cause unknown; affects external female reproductive organs Usually occurs after menopause Accounts for 3% to 4% of all cancers of the female reproductive system.	Squamous and basal cell cancers (90% squamous, 4% basal, 6% rare cancers) that usually begin on skin surface and are mostly slow-growing. Untreated, cancer spreads to vagina, urethra, anus, or lymph nodes.	Unusual lumps or sores Vulvar pruritus Bleeding Small painful, infected ulcer Groin pain Abnormal urination and defecation
*Cardiogenic shock*	?
Can result from conditions that cause significant ventricular dysfunction with reduced cardiac output, such as MI, myocardial ischemia, papillary muscle dysfunction, or end-stage cardiomyopathy	Decreased perfusion triggers baroceptor reflexes and fluid regulation mechanisms. The adaptive mechanisms eventually fail and positive feedback loops develop due to increased cardiac workload and tissue hypoxia. This may lead to extensive ischemic damage to vital organs such that the patient cannot recover.	Cold, clammy, pale skin Decrease in systolic blood pressure to 30 mm Hg below baseline Tachycardia Rapid, shallow respirations Restlessness and mental confusion Narrowing pulse pressure and cyanosis
*Carpal tunnel syndrome*	?
Mostly idiopathic or may result from trauma or repetitive motion of the wrist Many conditions, including alterations in the endocrine or immune systems, may increase the fluid pressure in the tunnel	Compression of the median nerve from inflammation or fibrosis of the tendon sheaths initially impairs sensory transmission to the thumb, index finger, second finger, and inner aspect of the third finger.	Weakness, pain, burning, numbness, or tingling in both hands Paresthesia affects thumb, forefinger, middle finger, and half of the fourth finger Inability to clench fist Nails may be atrophic Dry and shiny skin
*Celiac disease*	?
Results from a complex interaction involving dietary, genetic, and immunologic factors	Ingestion of gluten causes injury to the villi in the upper small intestine, leading to a decreased surface area and malabsorption of most nutrients. Inflammatory enteritis also results, leading to osmotic diarrhea and secretory diarrhea.	Recurrent diarrhea, abdominal distention, stomach cramps, weakness, or increased appetite without weight gain Normochromic, hypochromic, or macrocytic anemia Osteomalacia, osteoporosis, tetany, and bone pain in lower back, rib cage, and pelvis Peripheral neuropathy, paresthesia, or seizures Dry skin, eczema, psoriasis, dermatitis herpetiformis, and acne rosacea Amenorrhea, hypometabolism, and adrenocortical insufficiency Mood changes and irritability
*Cerebral aneurysm*	?
May be due to atherosclerosis, trauma, congenital defect, inflammation, infection, or cocaine use	A single pathologic mechanism does not exist.	Several days before event: Headache Stiff legs and back Nuchal rigidity Nausea Onset abrupt without warning: Severe headache Vomiting Altered consciousness Coma
*Cervical cancer*	?
Cause unknown; predisposing factors include intercourse under age 16, multiple sex partners, multiple pregnancies, and venereal infections Two types of cervical cancer: preinvasive and invasive	Preinvasive cancer is curable with early detection causing minimal cervical dysplasia in the lower third of the epithelium. Invasive cancer penetrates basement membrane to disseminate throughout the body via lymphatic routes. Histologic type is 95% squamous cell carcinoma.	Preinvasive cancer: Early invasive cancer shows no clinical changes or symptoms Abnormal vaginal bleeding Persistent vaginal discharge Postcoital pain and bleeding Advanced stages: Pelvic pain Vaginal leakage of urine or feces from fistula Anorexia, weight loss, and anemia
*Cervical spondylosis*	?
Caused by narrowing of cervical canal or neural foramina due to degenerative changes in the intervertebral disk and annulus and to bony osteophytes	Progressive myelopathy leads to cord compression, causing a spastic gait.	Arm weakness and atrophy with reflex loss Hyperreflexia and increased tone Plantar extensor response in legs
*Chalazion*	?
Due to obstruction of the meibomian (sebaceous) gland duct	Blockage of the meibomian gland leads to the formation of granulation tissue.	Local swelling Mild irritation Blurred vision Red-yellow elevation on conjunctival surface under eyelid
*Chédiak-Higashi syndrome*	?
Linked to consanguinity and transmitted as an autosomal recessive trait	A genetic defect that manifests in morphologic changes in the granulocytes and causes delayed chemotaxis and impaired intracellular digestion of organisms; diminished inflammatory response results.	Recurrent bacterial infections, primarily in the skin, lungs, and subcutaneous tissue Fever Thrombocytopenia, neutropenia, and hepatosplenomegaly Significant photophobia Motor and sensory neuropathies Cellular proliferation of liver, spleen, and bone marrow is fatal
*Cholera*	?
Acute enterotoxin-mediated GI infection due to gram-negative bacillus, which is transmitted through water and food contamination with fecal material from carriers or people with active infections	Following ingestion of a significant inoculum, colonization of the small intestine occurs. The secretion of a potent enterotoxin results in a massive outpouring of isotonic fluid from the mucosal surface of the small intestine. Profuse diarrhea, vomiting, fluid and electrolyte loss occurs and may lead to hypovolemic shock, metabolic acidosis, and death.	Incubation period is several hours to 5 days Acute, painless, profuse watery diarrhea, and vomiting Intense thirst, weakness, and loss of skin tone Muscle cramps Cyanosis Oliguria Tachycardia Falling blood pressure, fever, and hypoactive bowel sounds
*Chronic fatigue syndrome*	?
Cause unknown; may be found in HHV-6 or other herpesviruses, enteroviruses, or retroviruses	Infectious agents or environmental factors trigger an abnormal immune response and hormonal alterations.	Prolonged, overwhelming fatigue Centers for Disease Control and Prevention use a “working case definition” to group severity and symptoms
*Coccidioidomycosis*	?
Fungal infection due to possible inhalation of Coccidioides immilis spores from the soil or in plaster casts or dressing of infected people	C. immilis induces a granulomatous reaction that results in caseous necrosis.	Acute or subacute respiratory symptoms Dry cough, pleuritic chest pain, and pleural effusion Fever and sore throat Chills, malaise, headache, and itchy macular rash Tender red nodules on legs with joint pain in knees and ankles in Caucasian women Chronic pulmonary cavitation
*Colorado tick fever*	?
Virus is transmitted to human by a hard-shelled wood tick, Dermacentor andersoni . Tick acquires the virus when it bites an infected rodent and remains a permanently infected vector	Virus circulates inside of erythropoietic cells, producing typical febrile symptoms.	Incubation is 3 to 6 days; symptoms begin abruptly Chills, high temperature, severe back, arm and leg aches, and lethargy Headache with ocular movement Photophobia, abdominal pain, nausea, and vomiting
*Complement deficiencies*	?
Primary complement deficiencies inherited as autosomal recessive traits; however, C1 esterase inhibitor is autosomal dominant Secondary deficiencies may follow complement-fixing immunologic reactions	Series of circulating enzymatic serum proteins with nine functional components labeled C1-C9. This disease may increase susceptibility to infections and certain autoimmune disorders.	Clinical effects vary with specific deficiency C5 deficiency (familial defect in infants): Diarrhea and seborrheic dermatitis C1 esterase inhibitor deficiency: Swelling in face, hands, abdomen, or throat, with possible fatal laryngeal edema C2 and C3 deficiencies and C5 familial dysfunction: Increase susceptibility to bacterial infection C2 and C4 deficiencies: Collagen vascular disease (lupus and chronic renal failure)
*Costochondritis*	?
Cause unknown	An inflammatory process of the costochondral or costosternal joints is initiated, causing localized pain and tenderness.	Sharp pain in chest wall Area is sensitive to touch Pain may radiate into arm Pain worsens with movement Reproducible pain
*Creutzfeldt-Jakob disease*	?
Prion infection	Organism infects the CNS, leading to myelin destruction and neuronal loss.	Myoclonic jerking, ataxia, aphasia, visual disturbances, paralysis, and early abnormal electroencephalogram
*Cryptococcosis*	?
Fungal infection due to Cryptococcus neoformans , which is transmitted in particles of dust contamination by pigeon feces	Transmission is by inhalation of cryptococci. An asymptomatic pulmonary infection disseminates to extrapulmonary sites, usually CNS, but also skin, bones, prostate gland, liver, or kidneys. Left untreated, infection progresses from coma to death due to cerebral edema or hydrocephalus.	Fever, cough with pleuritic pain, and weight loss Severe frontal and temporal headache, diplopia, blurred vision, dizziness, aphasia, and vomiting Skin abscesses and painful lesions of the long bones, skull, spine, and joints
*Cystic echinococcosis*	?
Infection due to tapeworm larvae, Echinococcus gramulosus, E. multilocularis , or E. vogeli Mainly transmitted by dogs that ingested the viscera of infected sheep Also found in coyotes, wolves, dingoes, and jackals	E. granulosus forms cysts in the liver, lungs, kidneys, and spleen; infection can be treated with surgery. E. multilocularis (alveolar hydatid disease) forms parasite tumors in the liver, lungs, brain, and other organs; infection can be fatal.	Slow-growing cysts may be asymptomatic for years. Symptoms reflect location and size of cysts.
*Cystinuria*	?
Inherited autosomal recessive defect Prevalent in short people; cause unknown	Impaired function of membrane carrier proteins essential for transport of cystine and other dibasic amino acids results in excessive amino acid concentration in urine and excessive urinary excretion of cystine.	Dull flank pain and capsular distention from acute renal colic; hematuria Tenderness in the costovertebral angle or over the kidneys Urinary obstruction with secondary infection (fever, chills, frequency, and foul-smelling urine)

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