CD14分子

CD14 分子 ? CD14 常用單克隆抗體或代號：Mo2,UCHM1,LeuM3,MY4 主要表達細胞：M,G,DC,LHC [M] 分子質量(kDa)和結構：gp55(GPI連接) 功??? 能：LPS/LBP復合體受體 ? ? CD14 Aka lipopolysaccharide (LPS) receptor, endotoxin receptor Binding of LPS to CD14 on macrophages causes their activation and release of cytokines Involved in the clearance of apoptotic cells Also regulates IgE levels Positive staining (normal): macrophages/monocytes (90%), granulocytes-weak (30%), Langerhans cells; dendritic cells, B cells Positive staining (disease): B-CLL (90%), follicular center cell lymphoma (80%), diffuse large B cell lymphoma (40%); AML-M4/M5 (50-90%) Negative staining: myeloid progenitors, AML M3, M6, M7, M0-M2 (usually)