Journal of Chromatography A, 1259 (2012) 3–15
Recent developments in liquid chromatography–mass spectrometry and related techniques
Michal Holˇcapek, Robert Jirásko, Miroslav Lísa
Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentská 573, 53210 Pardubice, Czech Republic
Abstract
綜述了在過去10年LC-MS和相關的技術進展。初學者或者中等經驗的LC-MS使用者常會被市場上數量繁多的、不同的LC-MS系統所困擾，因此這篇文章綜述了主要生產廠家的LC-MS及MALDI-MS的配置、設計，并從第三方評估其優點和缺陷。包括當前質量分析器、離子化技術、快速LC-MS、LC-MALDI-MS、用于LC-MS中的離子遷移技術，質譜的定量特點等趨勢，也在這里討論了一些新興的質譜方法。
This review summarizes the state-of-art in liquid chromatography–mass spectrometry (LC–MS) and related techniques with the main focus on recent developments in the last decade. LC–MS records an enormous growth in recent years due to the application potential in analytical chemistry, biochemistry, pharmaceutical analysis, clinical analysis and many other ?elds, where the qualitative and quantitative characterization of complex organic, bioorganic and organometallic mixtures is needed. Beginners and moderately experienced LC–MS users may be confused by the number of different LC–MS systems on the
market, therefore an actual overview of mass spectrometers designed for the LC–MS con?guration and matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) from main manufacturers is compiled here together with an independent assessment of their advantages and limitations. Current trends in terms of mass analyzers, ionization techniques, fast LC–MS, LC–MALDI-MS, ion mobility spec-
trometry used in LC–MS, quantitation issues speci?c to MS and emerging mass spectrometric approaches complementary to LC–MS are discussed as well.
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yanzheng314 / 2013-10-15 13:48:58
