LDN Labor Diagnostika Nord-SHBG ELISA (RUO) Kit:血清或血漿中性激素結合球蛋白(SHBG)的酶免疫測定。

艾美捷LDN Labor Diagnostika Nord-SHBG ELISA (RUO) Kit(AA E-1200R):
名稱:SHBG ELISA
描述:
用于血清或血漿中性激素結合球蛋白(SHBG)定量測量的酶免疫測定法。
設計:ELISA
樣本體積:
50微升預稀釋的血清或血漿
總檢測時間:2小時45分鐘
標準范圍:0/4 – 260納摩爾/升
靈敏度:0.408納摩爾/升
儲存條件:2 – 8°C
試劑盒:96次測定
CE認證:是
LDN Labor Diagnostika Nord-SHBG ELISA (RUO) Kit檢測原理:
性激素結合球蛋白(SHBG)是一種95kD的同源二聚體糖蛋白,在肝臟中合成,在血漿中的半衰期為7天。SHBG以高親和力特異性結合類固醇激素(DHT>睪酮-雌二醇;DHEA/雄烯二酮/雌三醇),其主要功能是性類固醇在血流內和血管外靶組織中的轉運。SHBG還通過性類固醇對可用結合位點的競爭和SHBG濃度的波動,在調節生物可利用性類固醇濃度方面發揮關鍵作用。血液中SHBG濃度表現出高度的個體間變異性,并受雄激素/雌激素平衡、營養狀況、體重指數、性別、胰島素濃度等因素的影響。
LDN Labor Diagnostika Nord-SHBG ELISA (RUO) Kit參考文獻:
1. Moore, JW and Bulbrook RD. The epidemiology and function of sex hormone binding globulin.IN Oxford Rewievs of Reproductive Biology, 1988; 10: 180 - 236.
2. Selby, C. Sex hormone binding globulin: origin, function and clinical significance.Ann. Clin. Biochem. 1990; 27: 532 - 541.
3. Tehernof A, Despres JP: Sex steroid hormone, sex hormone-binding globulin, and obesity in men andwomen.Horm. Metab. Res.2000; 32:526-536.
4. Kahn SM, Hryb DJ, Nakhle AM, Romas NA: Sex hormone-binding globulin is synthesized in target cells.J Endocrinol 2002; 175:113-120.
5. Hammond GL: Access of reproductive steroids to target issues.Obstet Gynecol Clin North Am 2002; 29:411-423.
6. 5. Elmlinger MW, Kuhnel W, Ranke MB: Reference ranges for serum concentrations of lutropin (LH),follitropin (FSH), estradiol (E2), prolactin, progesterone, sex hormone binding globulin (SHBG),dehydroepiandrosterone sulfate (DHEA-S), cortisol and ferritin in neonates, children, and young adults.Clin Chem Lab Med 2002; 40(11):1151-1160.
7. Deswal ., Yadav A, Dang AS Sex hormone binding globulin - an important biomarker for predictingPCOS risk: A systematic review and meta-analysis.Syst Biol Reprod Med 2018; 64: 12-24.
8. Sanches de Melo et al. Hormonal contraception in women with polycystic ovary syndrome: choices,challenges, and noncontraceptive benefits.Open Access J Contracept.2017; 2;8:13-23.
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