為什么選擇MS-Xelerator快速質譜數據系統？ 高速分析、性價比最高、用戶體驗友好 簡單易學，對操作者無特殊要求 市場上速度最快的軟件 非常快速、全面的質譜數據分析軟件 同時適合LC-MS、GC-MS、CE-MS數據 圖形化顯示結果 快速強大的峰挑選算法和獨特的過濾算法 代謝組學、定量蛋白質組學、雜質分析、差異分析 生物標記物發現的理想工具 |
| 蛋白質分離、純度檢測和定量分析 |
| 雜質輪廓（譜）分析 |
| 降解產物輪廓（譜）分析 |
| 代謝產物輪廓（譜）分析 |
| 差異分析 |
| 代謝組學 |
| 定量蛋白質組學 |
| 生物標記物發現 |
‘We successfully used the Reference Peak Warping (RPW) function of the MsXelerator software to align profiles of rat-urinary metabolites obtained by capillary electrophoresis–mass spectrometry. The excellent alignment allowed reliable principal component analysis revealing significant differences between antibiotic-treated and non-treated rats.’ Miranda de Kok, PhD, Biomedical Analysis, Dept. of Pharmaceutical Sciences, Faculty of Science University Utrecht, the Netherlands
“我們使用MsXelerator軟件的RPW功能成功地校準了大鼠尿液代謝物的毛細管電泳-質譜數據。MsXelerator出色的校準功能保證了后續的主成分分析得以成功揭示抗生素治療組和非治療組大鼠尿液代謝物顯著差異。” Miranda de Kok，博士，生物醫學分析系，藥學院，烏德勒支大學，荷蘭‘We really enjoy working with MsMetrix to implement MsXelerator software according to our needs.? MsXelerator software, especially the part of the IPeaks module is a very powerful tool to process our routine reactive metabolite trapping data.’ Chenghong Zhang, Genentech (A Member of Roche), San Francisco, USA
“我們很樂意根據我們的需求使用MsMetrix公司的MsXelerator軟件實施我們的工作。MsXelerator軟件，尤其是IPeaks模塊，是一個處理常規活性代謝物捕集數據的強大工具。” 張成洪，Genentech公司（羅氏公司的一員），舊金山，美國‘MsXelerator enabled us to select peptides from very complex mixtures by recognition of their specifically induced isotope pattern. Manual inspection of thousands of spectra has been replaced by an hour of analysis time using MsXelerator.’ Dr. P.A. van Veelen, LUMC, Head Mass Spectrometry Group, Leiden, the Netherlands
“通過MsXelerator，我們可以從非常復雜的混合肽中識別出具有特異誘導同位素模式的肽。應用MsXelerator分析 1小時就可以替代我們人工成千上萬次的光譜檢測工作。” P.A.van Veelen，博士，萊頓大學醫學中心，質譜主席，萊頓，荷蘭‘At Evolva SA, we have been using MsXelerator with great success for more than 4 years. Finding unknown molecules in complex sample matrix requires challenging and extensive LC/MS data mining, without mentioning the time needed to review high throughput screening data. MsXelerator software and particularly the module MPeaks does a great job in deconvoluting and comparing MS chromatograms in order to find the small differences which are relevant for our applications. Moreover, the clever interactivity between MPeaks and MS-compare help us accelerating our analysis thanks to the multiple filters and statistical tools, all with great confidence. Beyond all doubt, MsXelerator is a powerful all-in-one software platform to process LC/MS data, removing the hassle of buying several expensive add-ons from the instrument vendors. I also particularly enjoy the collaboration, expertise and quick responsiveness of MsMetrix, regarding customization to our special requests! ’ Christophe Folly, Research Scientist, Evolva SA, Switzerland
“在Evolva SA公司，4年前我們已開始使用MsXelerator，至今已經獲得了巨大的成功。在復雜的樣品中尋找未知的分子，需要面臨的挑戰是深度的LC / MS數據挖掘以及高通量的數據篩選所需要的時間。MsXelerator 軟件特定的MPeaks模塊在解卷積和比對質譜數據以及找尋和我們應用相關的最小差異方面做得很好。此外，MPeaks 和MS-compare靈活的交互性幫助我們加速分析速度，其多重過濾和統計分析工具給了我們巨大的信心。毫無疑問，對于處理LC / MS數據，MsXelerator是一個集強大功能于一身的軟件平臺。除了幾個昂貴的組件需要從儀器供應商購買比較麻煩之外，我還特別欣賞MsMetrix公司的協作力、專業性以及對于我們特殊需求的快速響應力。” Christophe Folly，研究員，Evolva SA公司，瑞士‘MsXelerator is a real time-saver when processing our discovery and (pre)clinical Met-ID experiments at MSD (Schering-Plough, Organon).’ One workflow in a multi vendor ms lab. Searches for artificial isotope patterns at low level that worked (labeled compounds). Customization. Peter Jacobs, Head ADME Analysis, Schering-Plough
“在處理藥物發現和臨床Met-ID研究的質譜實驗數據時，MsXelerator可以真正為我們節省時間（Schering-Plough公司，Organon）。” ·在多個供應商的MS實驗室實現一個工作流程 ·搜索工作在較低水平的人造同位素模式（標記化合物） ·定制 Peter Jacobs，藥物動力學分析主席，Schering-Plough‘MsXelerator is an essential tool nowadays in processing our proteomics datasets. It provides sensitive algorithms to search for mass spectral doublets, either targeting absolute mass differences (in the context of e.g. SILAC-based proteomics experiments or chemical modifications of amino acids) or relative mass differences. This latter feature is unique in its kind, as it allocates14N/15N-isotopically labeled peptides characterized by a relative mass difference of 1.2% of the m/z-value of the peptide and user-specified peak intensity ratios. For our Immuno Proteomics research we often apply 14N/15N-metabolic labeling protocols to target MHC-presented epitopes. MsXelerator is exceptional in allocating these typical mass spectral doublets, based on relative mass differences, charge states and intensity ratios. All data processing is performed on the raw MS data, without any prior data conversion. MsXelerator also supports high resolution MS data (e.g. Orbitrap datasets) that significantly reduces the false positive hits and speeds up the automated processing of our complex and large data sets. The flexibility of the user interface, allows us to set and define many search parameters, depending on the design of the experiment. MsXelerator also features a good built-in browser to view the raw data (chromatograms, extracted ion chromatograms, mass spectra) without switching back and forth to the MS-vendor originating data system. It is without any doubt that this application has boosted our Immuno Proteomics research. Moreover, the good hands-on training and the direct contact with the software developers of MsXelerator allows us to have user-defined modules integrated in the basic version of the application. ’ Hugo D. Meiring, PhD, Scientist Biomolecular Mass SpectrometryUnit Vaccinology, Centre for Infectious Disease Control Netherlands, National Institute for Public Health and the Environment.
“MsXelerator是我們目前處理蛋白質組學數據集的一個重要的工具。它提供了靈敏的算法來搜索質譜中的雙峰，同時也適用于絕對質量差異（例如：基于SILAC的定量蛋白質組學實驗或化學修飾的氨基酸）和相對質量差異。 后者的特點是獨一無二的，其特點在于14N/15N同位素標記肽的分配，以m / z值的相對質量差為1.2％的肽和和用戶指定的峰強度比為特征。我們在免疫蛋白質組學的研究中，通常采用14N/15N代謝標記目標MHC的抗原決定簇。根據相對質量差、電荷狀態和強度比，MsXelerator在分配典型的質譜雙峰時是很完美的。可對所有的原始MS數據進行處理，無需任何預處理。 MsXelerator還支持高分辨率質譜數據（例如：Orbitrap的數據集），顯著地降低了假陽性出現，加快了自動處理復雜和龐大數據集的速度。用戶界面靈活，允許我們根據實驗的設計，設置并定義檢索參數。 MsXelerator還擁有一個內置的瀏覽器用于直接查看原始數據（色譜圖、離子色譜圖、質譜），無需切換至質譜供應商提供的原始數據系統查看數據。 毫無疑問，這個應用程序提升了我們在免疫蛋白質組學上的研究。此外，良好的培訓以及與MsXelerator軟件開發人員的直接聯系讓我們可以在基礎版本的基礎上擁有用戶自定義的集成模塊。” Hugo D. Meiring，博士，分子生物學、單位疫苗學質譜方向的科學家，來自荷蘭傳染病控制中心國家公共衛生和環境研究所。