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    PARP4基因編碼的功能和結構描述

    2022.8.18

    該基因編碼聚腺苷二磷酸核糖基轉移酶樣1蛋白,能催化聚腺苷二磷酸核糖基化反應。該蛋白具有與聚adp-核糖基轉移酶同源的催化結構域,但缺乏激活聚adp-核糖基轉移酶c端催化結構域的n端dna結合結構域。由于該蛋白不能直接與dna結合,其轉移酶活性可能被其他因素激活,如廣泛的羧基末端介導的蛋白質-蛋白質相互作用。

    This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus.

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