CD40分子

CD40 分子 ? CD40 常用單克隆抗體或代號： G28- 5,EA- 5 主要表達細胞： B,M,FDC,并指細胞,上皮 [B] 分子質量(kDa)和結構： gp50(TNFR- SF) 功??? 能： B細胞生長、分化和記憶細胞產生,配體為CD40L,T- B相互作用 ? CD40 Plays a central role in regulating cell-mediated immunity and antibody mediated immunity May mediate inflammatory component of atherogenesis Positive staining (normal): B cells, macrophages, dendritic cells, endothelial cells, fibroblasts, keratinocytes Positive staining (disease): carcinomas, most B cell lymphomas, B-ALL (some) Negative staining: plasma cells ?