CD61 分子 ? CD61 常用單克隆抗體或代號： Y2/51,CLB- thromb/1;(VNR- b 鏈,integrin b 3) 主要表達細胞： Pt,Meg [Pt] 分子質量(kDa)和結構： gp105,血小板GPⅢa,與CD51組成VNR,與CD41組成a Ⅱbb 3 功??? 能： 血小板凝集和活化 ? CD61 Aka platelet glycoprotein IIb/IIIa Receptor for fibrinogen, fibronectin, prothrombin, thrombospondin, vitronectin, plasminogen Mediates platelet aggregation by binding soluble fibrinogen, forming platelet plug Defects cause Glanzmann thrombasthenia, an autosomal recessive disorder and the most common inherited platelet disease Positive staining (normal): platelets, megakaryocytes, myeloid progenitor cells, endothelial cells Positive staining (disease): AML M7, AML M6 (some), blasts in transient myeloproliferative disorder Negative staining: AML M0-M5, M6 (most) Micro images: megakaryoctyes (figures C, D) ?