CD64 分子 ? CD64 常用單克隆抗體或代號： MAb32.2,MAb22;(Fcg RI) 主要表達細胞： M [M] 分子質量(kDa)和結構： gp75(IgSF) 功??? 能： 吞噬、ADCC,Mac活化 ? CD64 Aka Fc gamma RI High affinity receptor binds to Fc region of IgG Important in phagocytosis via receptor-mediated endocytosis of IgG-antigen complexes Mediates antigen capture for presentation to T cells, antibody-dependent cellular cytotoxicity, release of cytokines and reactive oxygen intermediates Positive staining (normal): Macrophages/monocytes, activated granulocytes, dendritic cells, early myeloid cells Positive staining (disease): AML M0-M2 (variable); M3 (usually); M4, M5 Negative staining: AML M7 ?