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Oligonucleotide Analogs Containing Dephospho-Internucleoside Linkages
關鍵詞： oligonucleotide analogs來源： 互聯網
Nonionic oligonucleotide analogs have attracted much interest in recent years as potential candidates for oligonucleotide-based therapeutics. Compared to their natural parent molecules, they are expected to have the advantage of:
| 1.? | Being stable against degrading nucleases, |
| 2.? | Showing enhanced cellular uptake, and |
| 3.? | Having the ability to form more stable complexes with complementary sequences owing to reduced charge repulsion. |
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