徠卡推出用于活細胞成像的DMi8 S

概述

最新產品包括一個Synapse實時控制器，用于收集更精細的時間分辨數據。

徠卡推出了DMi8 S，被描述為一個完整的解決方案，可以對活細胞進行快速、多功能的顯微成像。

帶有LASX Navigator的DMi8 S允許研究人員快速創建高分辨率的概述，例如，整個小鼠大腦。

這有助于在樣本上定位，并容易發現關鍵區域以供進一步檢查。

用多色免疫熒光標簽掃描小鼠腦組織的圖像。[中國廈門大學生命科學學院魏默博士]

徠卡微系統公司總裁馬庫斯·盧瑟說：“活細胞成像是未來的發現。了解動態過程是理解人類疾病的機制、潛在治療和預防的關鍵。”。“這些新開發的DMi8具有深遠的實用價值。無論是研究神經科學、癌癥還是免疫學，研究人員都可以使用DMi8來獲得他們問題的難以捉摸的答案，并找到與我們復雜生物學的聯系。”

徠卡的DMi8 S成像解決方案提供了5倍的速度，并增加了高達10000X的觀看面積。

這可以與新的光操作掃描儀相結合，在一次實驗中激活、消融和漂白。

對于超分辨率和納米級，增加了無限TIRF，可以同時進行單分子分辨率的多色成像。

這讓研究人員能夠看到更多、更快，并找到隱藏的東西，開啟了寬場成像的下一個篇章。

DMi8 S的核心是一個新添加的Synapse實時控制器，使用戶能夠更快地獲取數據，并收集更精細的時間分辨數據。

此外，新的LAS X Navigator是一個功能強大的GPS風格的概覽工具，可以可視化所有類型的樣本，包括幻燈片、盤子和多孔板。

徠卡利用DMi8 S的模塊化無限端口結構，通過無限TIRF和無限掃描儀增加了先進的熒光功能。

通過Infinity TIRF模塊，研究人員可以同時執行多色EPI、Hi Lo和TIRF照明，以及GSD/dSTORM和PALM等超分辨率應用的高功率照明選項。

Infinity Scanner photomanipulation模塊為用戶提供了前所未有的多模式能力，可以使用可光激活和可光切換熒光蛋白的最新發展。

研究人員現在可以通過在一個實驗中執行光漂白、光轉換、光遺傳學和消融等任務，直接與活細胞互動并啟動活細胞中的事件。

Leica launches DMi8 S for live cell imaging

Overview

Latest product includes a Synapse real-time controller for gathering finer time-resolved data.

Leica has introduced the DMi8 S, described as a complete solution for fast, versatile microscopic imaging of living cells. 

The DMi8 S with LASX Navigator allows researchers to quickly create high resolution overviews of, for example, the whole mouse brain. 

This facilitates orientation on the sample and easy discovery of critical regions for further examination. 

Tile scan image of Mouse brain tissue with multi-colour immunofluorescent labelin. [Dr. Wei Mo, School of Life Sciences, Xiamen University, China]

"Live-cell imaging is the future in discoveries. Gaining insight on dynamic processes is key to understand the mechanisms, potential treatments and prevention of human diseases," says Markus Lusser, President of Leica Microsystems. "These new DMi8 S developments have far reaching utility. Whether studying neuroscience, cancer, or immunology, researchers can use the DMi8 S to get elusive answers to their questions and find the links to our complex biology."

The DMi8 S imaging solution from Leica provides 5x more speed, and an increased viewing area up to 10,000x. 

This can be combined with the new photomanipulation scanner to activate, ablate, and bleach within one experiment. 

For super resolution and nanoscopy, the Infinity TIRF has been added allowing simultaneous multi-colour imaging with single molecule resolution. 

This allows researchers to see more, see faster, and find the hidden, opening up the next chapter in widefield imaging. 

At the heart of the DMi8 S is a newly added Synapse real-time controller that enables users to get their data more quickly and gather finer time-resolved data. 

In addition the new LAS X Navigator is a powerful GPS style overview tool to visualize all types of samples including slides, dishes and multi well plates. 

Utilizing the modular Infinity Port architecture of the DMi8 S, Leica has added advanced fluorescence capabilities with the Infinity TIRF and the Infinity Scanner. 

With the Infinity TIRF module, researchers can execute simultaneous multicolor EPI, Hi-Lo and TIRF illumination as well as a high power illumination option for super resolution applications like GSD/ dSTORM and PALM. 

The Infinity Scanner photomanipulation module gives users an unprecedented multimodal ability to use the latest developments in photoactivatable and photo switchable fluorescent proteins. 

Researchers can now interact directly with and initiate events in living cells by performing a combination of tasks like photobleaching, photoconversion, optogenetics and ablation within a single experiment.